study guide for chapters 3-5

 

Chapter 6,7,9,10

 

Complete Study Guide

    *With interactive Table of Contents and improved CH.8  questions

 

Chapters 1 and 2 – review thoroughly

 

 

 

Chapters 3, 4 & 5 - Focus on being able to answer following q’s:

What is resonance (simple explanation)?  What determines resonance in MR and how is it used to select slice. (Ch3, q5, 8, 10, 12)

How is location determined within slice (e.g. see ch4 q 7, 16)

Be able to explain difference between T1 vs. T2 (ch3, q14-16; ch 5, q6-10)

What is a fourier transform? (simple explanation - current answer Ch4 q8 on wiki not adequate – look it up)

How does k-space differ from ‘normal space’ illustrate this with some concrete examples (see ch4, q’s 5, 11, 12, 14)

Why are slices interleaved, how does this affect temporal characteristics of fMRI? (for first part, see Ch4, q15)

What is TR and TE (Ch5, q3,4)

What is a susceptibility artifact? (Ch5, q18)

 

 

 

Chapters 6 & 7

Focus on location in the brain, and ability to actually recognize and label views of the brain (q’s 9-12, but make sure you know what these look like!)

Provide a coherent explanation of the steps relating neuronal activity relates to BOLD signal. Include the following:

What influences blood flow? (Ch6, q18)

What magnetic properties is the BOLD sensitive to? (Ch7, q1)

What does BOLD stand for? (Ch7, q 6)

What causes BOLD contrast? (Ch7, q7)

What influences spatial resolution of BOLD? (Ch7, q9)

Why might BOLD be thought of as a quirk? (Ch7, q 12)

What special type of BOLD effect might have better spatial resolution, but has yet to be clearly seen (Ch7, q13)

 

 

 

Additional study

 

You should be able to draw the bold response due to the following. Graphs should have correctly labelled x and y axes with approximately correct times and % BOLD modulation values. (covered in Ch7, q 18,19,20; Ch8)

(excel version of graphs would be excellent!)

1)      A brief event (0.5 sec duration)

2)      Two brief events separated in time by 2 secs (draw both summed and separate responses)

3)      Two brief events separated in time by 6 secs (draw both summed and separate responses)

4)      A repetitive sequence of events (>10) occurring over a time period of 15 secs. E.g. a block of events

 

 

 

Chapter 8 – review thoroughly (current version of chapter answers could be improved)

 

 

 

Chapter 9 focus on following:

Define ‘signal’ and ‘noise’ (q1)

Describe different types of signal to noise (q2)

What are common forms of physiological noise (q7)

How does the balance between different types of noise change with field strength (q15)

 

 

 

Chapter 10 focus on the following

What is preprocessing vs experimental analysis? (q1)

What is the first rule of quality assurance? (q2)

Why do we do slice timing corrections? (q4)

How do researchers correct for head motion (q9)

Why do coregistration? (q11)

Why do normalization? (q13)

What are the problems with normalization? (q16)

Why smooth? (q 17)

Explain the problem of multiple comparisons in brain imaging (q18)

What is temporal filtering? Why do low pass filtering? Why do high pass filtering? (p21)

 

 

 

Chapters 11 and 12 – review thoroughly